Generic Tegopen (Cloxacillin)
Tegopen is a penicillin type antibiotic prescribed in treatment of infections of respiratory and urinary tracts.
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Product Description
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Common use

Tegopen is an antibacterial medication from the group of semi-synthetic penicillins. It kills bacteria by blocking bacterial synthesis of cell wall and hereby prevents propagation of the microorganisms. It is active against gram-positive and gram-positive cocci: Neisseria meningitidis and Neisseria gonorrhoeae, Corynebacterium diphtheriae, Haemophilus influenzae, Bacillus anthracis. Tegopen is stable in acidic media and to the action of penicillinase. Cloxacillin is used to treat infectious and inflammatory diseases caused by the susceptible organisms such as abscesses, carbuncles, furunculosis, sinusitis, otitis media, pharyngitis, tonsillitis, paratonsillar abscess, pneumonia, pleural empyema, meningitis, endocarditis, sepsis, osteomyelitis, urinary tract diseases, prevention of complications on transplantation of skin graft.

Dosage and direction

Take exactly as prescribed by your doctor. Recommended dose for adults is 500 mg four times a day, one for 2-10 y.o. Kids is 250 mg four times a day, children younger than 2 y.o. should take 125 mg of Tegopen four times a day. Drink a full glass of water after you took each dose on an empty stomach at least one hour before or two hours after a meal. Do not drink soda or other carbonated beverages as they are able to decrease effectiveness of the treatment. Take this medication regularly at evenly spaced intervals to get the best results. Do not crush, chew, or open the capsules, just swallow them whole. If it is the suspension liquid of Tegopen shake it before usage and measure with a special spoon. Do not stop taking this medication without recommendation of your doctor even if your symptoms improved as your infection may not be completely treated.


Inform your doctor if you have such conditions as kidney disease, stomach or intestinal illnesses, infectious mononucleosis, diabetes, or allergic to any penicillines. Avoid taking alcohol if you are treated with Tegopen as it is able to worsen its side effects.


Hypersensitivity to the components of Tegopen.

Possible side effect

If during treatment with Tegopen you experience hives, itching, nausea, heartburn, diarrhea, anaphylactic shock, seizures, severe watery diarrhea and abdominal cramps, unusual bleeding or bruising just stop taking it and notify your doctor about your symptoms as you may need immediate medical help.

Drug interaction

Antacids, glucosamine, laxatives, food, aminoglycosides slow down and reduce absorption of Tegopen while ascorbic acid increases it. Co-administration of bactericidal antibiotics (including cephalosporin, cycloserine, vancomycin, rifampin), aminoglycosides co-administered with Tegopen has a combined effect, which exceeds the action of each separate component. Tegopen is an antagonist toward bacteriostatic antibiotics (including macrolides, chloramphenicol, linkosamidy, tetracyclines). Tegopen increases effectiveness of anticoagulants by suppressing the intestinal microflora, reducing prothrombin index. It reduces effectiveness of oral contraceptives. Diuretics, allopurinol, blockers of tubular secretion, phenylbutazone, NSAIDs which decrease the tubular secretion, increase blood levels of Tegopen. Concomitant use with allopurinol increases risk of allergic reactions (rash).

Missed dose

If you forgot to take this medication take it as soon as you remember. If it is almost time of your next dose just skip the missed dose and return to your regular schedule.


In case you experience muscle spasms or weakness, pain or twitching, ache in the fingers or toes, numbness in the fingers or toes, seizures, confusion, coma, or agitation during treatment with Tegopen, seek for immediate medical help.


Store Tegopen capsules at room temperature. Tegopen suspension should be kept in the refrigerator for longer use. The suspension is valid for 14 days if it is stored in the refrigerator. Do not use any remnants of the liquid after this amount of time.


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

How does Lasix work and what pharmaceutical group does it belong to?

Lasix is a diuretic agent. Lasix causes a short term diuresis. Lasix action mechanism is associated with the reabsorbtion block of chloride and sodium ions in the Henle's loop.Lasix works by increasing excretion of K+, Ca2+, Mg2+ out of the organism. Hypotensive effect of the medication is associated with increased elimination of sodium and water.

Which conditions are treated with Lasix?

Lasix is used for the treatment of the following conditions:

  • Edema syndrome in chronic cardiac failure(II - III stage)
  • Cirrhosis
  • Kidney diseases
  • Cerebral edema
  • Hypertensive crisis
  • Hypertension
  • High calcium blood level

What should a patient know before using Lasix?

The Lasix should not be used in cases of:

  • Hypersensitivity
  • Severe renal failure
  • Acute liver failure
  • Ankylurethria
  • Acute glomerulonephritis
  • Hyperglycemic coma
  • Hyperuricemia
  • Arthragra
  • Decompensated mitral or aortal stenosis
  • Hypotension
  • Acute myocardial infarction
  • Pancreatitis
  • Digitalis intoxication

The drug should be used with caution in the following conditions:

  • Prostatic Hyperplasia
  • Systemic lupus erythematosus
  • Diabetes
  • Pregnancy
  • Breastfeeding

Which adverse effects may manifest when using the medication?

The side effects of Lasix include:

  • Cardiovascular system: hypotension, postural hypotension, collapse, tachycardia, arrhythmia, volume of blood circulation decrease.
  • Central nervous system: dizziness, headache, myasthenia, cramp in leg, paresthesia, apathy, adynamia, weakness, drowsiness,
  • Sense organs: vision and hearing disorders.
  • Gastrointestinal tract: appetite reduce, xerostomia, nausea, vomiting, constipations and diarrhea, pancreatitis.
  • Urinary system: oliguria, acute retention of urine, interstitial nephritis, erythrocyturia, decrease of sexual potency.
  • Allergic reactions: purpura, urticaria fever, exfoliative dermatitis, vasculitis, skin rash, shakes, fever.
  • Hematopoietic system: leukopenia, thrombocytopenia, agranulocytosis, anemotrophy.
  • Water-electrolyte balance: hypovolemia, anhydration, hypokalemia, hyponatremia, hypomagnesemia, metabolic alkalosis.

It is not necessary that the side effects will manifest in an individual but the possibility still exist. For more information please consult your health care provider.

Which groups of drugs or specific preparations may interact with Lasix?

The drug is affected by the following:

  • Immunodepresants
  • Aminoglycosides
  • Antimicrobial agents
  • Diuretics
  • Antineoplastics
  • Antimycotics
  • Antiulcer agents
  • Bronchodilating agents
  • Hypotensive preparations
  • Glucocorticosteroids
  • Cardiac glycosides

Tell your doctor about all the herbal preparations as well as prescription drugs that you are currently taking even if they are not on the list.

Important information for the patient:

Lasix is supplied for individual use. Do not use it to treat other conditions not listed in the leaflet. Keep the product out of children reach. Do not reuse any disposable materials if supplied with the preparation.