Generic Mestinon (Pyridostigmine)
Mestinon is used to treat myasthenia gravis or intestinal atony and atonic constipation, it works increasing muscle tone of smooth muscles in different organs.
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Product Description

Speaking: Mestinon

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Common use

Mestinon contains pyridostigmine bromide and is used to treat myasthenia gravis. The medicine inhibits acetylcholinesterase and increases effects of acetylcholine. It improves neuromuscular transmission, increases gastrointestinal motility, increases muscle tone of the bladder, bronchi, and secretion of exocrine glands, causes bradycardia, miosis, spasm of accommodation.

Dosage and direction

To treat intestinal atony and atonic constipation take orally 60 mg every 4 hours, to treat acute myasthenia gravis use 60-180 mg of the medication 2-4 times a day. Te dose may be increased by your doctor. Swallow the pills whole, do not crush, chew or break extended-release tablets. Do not take double dose of this medication. Take your usually dose next day in the same regularly time.


Inform your doctor if you have asthma or kidney disease. Your dose may be increased by your doctor. Follow all recommendations of your health care advisor. Inform your doctor about your hypotension, acute myocardial infarction, ulcers in stomach and duodenum, bradycardia, diabetes, stomach surgery, pregnancy.


This medication cannot be used in patients with peritonitis, and a bladder or bowel obstruction. Do not take Mestinon if you have been treated by depolarizing muscle relaxants (suxametone, dekametone), have hypersensitivity to Mestinon, suffer with iritis, asthma, obstructive ileus, a spasm of gastrointestinal tract, spasm of biliary or urinary tract, myotonia, Parkinson's disease, thyrotoxicosis (excess thyroid hormone production), post-operative shock, in pregnant women.

Possible side effect

Allergic reactions to the medication are possible, their symptoms include hives, skin rash, difficulty breathing, facial swelling. More serious adverse reactions are severe nausea, vomiting or diarrhea, extreme muscle weakness, problems with vision, muscle cramps or twitching, drop in blood pressure, excessive salivation, frequent urination, drop in blood pressure, bradycardia, miosis, convulsions, muscle twitching, myasthenia gravis.

Drug interaction

Atropine reduces effects of Mestinon. Mestinon used together with the depolarizing muscle relaxants, barbiturates and morphine derivatives increases their effects. Mestinon is contraindicated for use with ethanol. M-cholinoblockers, ganglioplegic drugs, quinidine, procainamide, local anesthetics, tricyclic antidepressants, antiepileptic drugs, and drugs for Parkinson's disease decrease effects of Mestinon.

Missed dose

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose.


Signs of overdose are nausea, vomiting, extreme muscle weakness, diarrhea, sweating, and muscle cramps, or weakness, involuntary defecation and urination, intestinal colic. Contact your doctor immediately if you experience any of the symptoms listed in this section.


Store in a dry tight container away from sunlight at room temperature between 15-30 C (59-86 F) away from children and pets.


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

How does Lasix work and what pharmaceutical group does it belong to?

Lasix is a diuretic agent. Lasix causes a short term diuresis. Lasix action mechanism is associated with the reabsorbtion block of chloride and sodium ions in the Henle's loop.Lasix works by increasing excretion of K+, Ca2+, Mg2+ out of the organism. Hypotensive effect of the medication is associated with increased elimination of sodium and water.

Which conditions are treated with Lasix?

Lasix is used for the treatment of the following conditions:

  • Edema syndrome in chronic cardiac failure(II - III stage)
  • Cirrhosis
  • Kidney diseases
  • Cerebral edema
  • Hypertensive crisis
  • Hypertension
  • High calcium blood level

What should a patient know before using Lasix?

The Lasix should not be used in cases of:

  • Hypersensitivity
  • Severe renal failure
  • Acute liver failure
  • Ankylurethria
  • Acute glomerulonephritis
  • Hyperglycemic coma
  • Hyperuricemia
  • Arthragra
  • Decompensated mitral or aortal stenosis
  • Hypotension
  • Acute myocardial infarction
  • Pancreatitis
  • Digitalis intoxication

The drug should be used with caution in the following conditions:

  • Prostatic Hyperplasia
  • Systemic lupus erythematosus
  • Diabetes
  • Pregnancy
  • Breastfeeding

Which adverse effects may manifest when using the medication?

The side effects of Lasix include:

  • Cardiovascular system: hypotension, postural hypotension, collapse, tachycardia, arrhythmia, volume of blood circulation decrease.
  • Central nervous system: dizziness, headache, myasthenia, cramp in leg, paresthesia, apathy, adynamia, weakness, drowsiness,
  • Sense organs: vision and hearing disorders.
  • Gastrointestinal tract: appetite reduce, xerostomia, nausea, vomiting, constipations and diarrhea, pancreatitis.
  • Urinary system: oliguria, acute retention of urine, interstitial nephritis, erythrocyturia, decrease of sexual potency.
  • Allergic reactions: purpura, urticaria fever, exfoliative dermatitis, vasculitis, skin rash, shakes, fever.
  • Hematopoietic system: leukopenia, thrombocytopenia, agranulocytosis, anemotrophy.
  • Water-electrolyte balance: hypovolemia, anhydration, hypokalemia, hyponatremia, hypomagnesemia, metabolic alkalosis.

It is not necessary that the side effects will manifest in an individual but the possibility still exist. For more information please consult your health care provider.

Which groups of drugs or specific preparations may interact with Lasix?

The drug is affected by the following:

  • Immunodepresants
  • Aminoglycosides
  • Antimicrobial agents
  • Diuretics
  • Antineoplastics
  • Antimycotics
  • Antiulcer agents
  • Bronchodilating agents
  • Hypotensive preparations
  • Glucocorticosteroids
  • Cardiac glycosides

Tell your doctor about all the herbal preparations as well as prescription drugs that you are currently taking even if they are not on the list.

Important information for the patient:

Lasix is supplied for individual use. Do not use it to treat other conditions not listed in the leaflet. Keep the product out of children reach. Do not reuse any disposable materials if supplied with the preparation.