Generic Lozol (Indapamide)
Lozol
Lozol is used to treat hypertension either alone or in combination with other high blood pressure medications.
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Product Description

Lozol - helpful

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Common use

Lozol is a thiazide-like diuretic which contains an active substance benzamide-sulfonamide-indole (Indapamide). By its pharmacological properties it is similar to thiazide diuretics (changes of Na+ re-absorption in the vertical segment of the loop of Henle). Lozol increases excretion of Na+, Cl-, K+, and Mg2+ with urine. It is used to treat hypertension either alone or in combination with other high blood pressure medications. Long treatment with Lozol is required, a therapeutic effect observed after 1-2 weeks of use, maximum is reached in 8-12 weeks and keeps up to 8 weeks.



Dosage and direction

Take Lozol once a day in mornings before breakfast with or without food. The usual initial dose is 1.25 mg taken as a single daily dose. It may be increased up to 5 mg.



Precautions

Lozol and other diuretics stimulate excretion of slats and potassium with urine which may lead to considerable loss of the substances especially among elderly women. Hypopotasse signs are muscle weakness and rapid or irregular heartbeat. For compensation of the potassium loss, you may be recommended to eat potassium-rich foods or taking a potassium supplement. Risk of hypopotassemia increases when larger doses are used, in the patients with cirrhosis, and in those treated by corticosteroids or ACTH. Blood pressure, K+ serum, and creatinine tests should be done regularly, especially in the individuals with an irregular heartbeat or those on heart medications. Systematic control of blood K+, Na+, Mg2+, pH, glucose uric acid and residual nitrogen is required especially in patients with gout or high uric acid levels, liver disease, diabetes, or lupus erythematosus, kidney dysfunction.



Contraindications

Lozol cannot be administered in patients with hypersensitivity to its components, severe liver or kidney failure (anuria), hypopotassemia. High doses of Lozol cannot be used to treat edematous syndrome in the patients with cerebrovascular accident and decompensated diabetes with ketoacidosis. Lozol cannot be used in individuals with lactose intolerance, galactosemia, a syndrome of glucose malabsorption for the medication which contain lactose. Cautiousness should be exercised in individuals with impairments of water-electrolyte balance, moderate liver or kidney failure, ascites, coronary artery disease, heart failure, hyperuricemia (gout), hyperparathyroidism, pregnant or breastfeeding women in elderly or adolescents under 18 years of age.



Possible side effect

Frequency of side effects depends on the dose of Lozol. They may appear as agitation, anxiety, dizziness, headache, back pain, diarrhea, vomiting, abdominal pain, dry mouth, infection, irritability, muscle cramps or spasms, numbness in hands and feet, nervousness, nasal inflammation, pain, tension, fatigue, weakness, loss of energy or tiredness.



Drug interaction

Lozol may cause hypopotasseimia and hypomagnesemia. Fatal arrhythmias may develop in patients on digoxin (Lanoxin) due to toxicity. Cardiac arrhythmias are also caused by use of amiodarone (Cordarone) and indapamide. Elimination of lithium by kidneys decreases in patients treated by diuretics and hereby leads to increase of lithium toxicity.



Missed dose

Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.



Overdose

You need immediate medical attention in case of Lozol overdose which may express through such symptoms as electrolyte imbalance, nausea, stomach disorders, vomiting, weakness.



Storage

Tablets of Lozol should be stored at room temperature between 15-30 C (59-86 F).



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

How does Lasix work and what pharmaceutical group does it belong to?

Lasix is a diuretic agent. Lasix causes a short term diuresis. Lasix action mechanism is associated with the reabsorbtion block of chloride and sodium ions in the Henle's loop.Lasix works by increasing excretion of K+, Ca2+, Mg2+ out of the organism. Hypotensive effect of the medication is associated with increased elimination of sodium and water.

Which conditions are treated with Lasix?

Lasix is used for the treatment of the following conditions:

  • Edema syndrome in chronic cardiac failure(II - III stage)
  • Cirrhosis
  • Kidney diseases
  • Cerebral edema
  • Hypertensive crisis
  • Hypertension
  • High calcium blood level

What should a patient know before using Lasix?

The Lasix should not be used in cases of:

  • Hypersensitivity
  • Severe renal failure
  • Acute liver failure
  • Ankylurethria
  • Acute glomerulonephritis
  • Hyperglycemic coma
  • Hyperuricemia
  • Arthragra
  • Decompensated mitral or aortal stenosis
  • Hypotension
  • Acute myocardial infarction
  • Pancreatitis
  • Digitalis intoxication

The drug should be used with caution in the following conditions:

  • Prostatic Hyperplasia
  • Systemic lupus erythematosus
  • Diabetes
  • Pregnancy
  • Breastfeeding

Which adverse effects may manifest when using the medication?

The side effects of Lasix include:

  • Cardiovascular system: hypotension, postural hypotension, collapse, tachycardia, arrhythmia, volume of blood circulation decrease.
  • Central nervous system: dizziness, headache, myasthenia, cramp in leg, paresthesia, apathy, adynamia, weakness, drowsiness,
  • Sense organs: vision and hearing disorders.
  • Gastrointestinal tract: appetite reduce, xerostomia, nausea, vomiting, constipations and diarrhea, pancreatitis.
  • Urinary system: oliguria, acute retention of urine, interstitial nephritis, erythrocyturia, decrease of sexual potency.
  • Allergic reactions: purpura, urticaria fever, exfoliative dermatitis, vasculitis, skin rash, shakes, fever.
  • Hematopoietic system: leukopenia, thrombocytopenia, agranulocytosis, anemotrophy.
  • Water-electrolyte balance: hypovolemia, anhydration, hypokalemia, hyponatremia, hypomagnesemia, metabolic alkalosis.

It is not necessary that the side effects will manifest in an individual but the possibility still exist. For more information please consult your health care provider.

Which groups of drugs or specific preparations may interact with Lasix?

The drug is affected by the following:

  • Immunodepresants
  • Aminoglycosides
  • Antimicrobial agents
  • Diuretics
  • Antineoplastics
  • Antimycotics
  • Antiulcer agents
  • Bronchodilating agents
  • Hypotensive preparations
  • Glucocorticosteroids
  • Cardiac glycosides
  • NSAID

Tell your doctor about all the herbal preparations as well as prescription drugs that you are currently taking even if they are not on the list.

Important information for the patient:

Lasix is supplied for individual use. Do not use it to treat other conditions not listed in the leaflet. Keep the product out of children reach. Do not reuse any disposable materials if supplied with the preparation.