Generic Imdur (Isosorbide)
Imdur is a nitrate which widens blood vessels and treats angina attacks (chest pain).
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Common use

Imdur belongs to nitrates. Effects of its active substance, Isosorbide mononitrate, consist in dilatation of (widening) of blood vessels and making it easier for the heart to pump. Imdur is used in treatment of angina attacks (chest pain). Other similar nitrates drugs include isosorbide dinitrate (Dilatrate-SR, Isochron, Isordil Titradose) and nitroglycerin (NitroQuick, Nitrolingual, Nitrostat, Nitro-Dur ).

Dosage and direction

The recommended dose of Imdur is 20 mg of immediate release tablets taken two times a day. Take the next dose at least seven hours later the previous dose to avoid tolerance. If you use The dose extended release tablets, the dose is 30-240 mg taken one time a day.


You should not take Imdur if you use sildenafil (Viagra) due to possible serious side effects. If you are allergic to isosorbide dinitrate, (Isochron, Isordil, Dilatrate), isosorbide mononitrate, or nitroglycerin you should not take Imdur. Also do not use the drug if you have early signs of a heart attack such as chest pain or heavy feeling, nausea, sweating, pain spreading to the arm or shoulder, general ill feeling.

Before taking Imdur, notify your health care advisor if you have congestive heart failure, low blood pressure, or kidney disease. At the beginning of treatment Imdur may cause serious headaches. Do not use Imdur to treat angina attack that has already started. This medication is used to prevent angina attack so use it according to instructions of your doctor. Do not stop taking this medication suddenly as it may cause a severe angina attack. Inform your doctor if you have congestive heart failure, low blood pressure, or kidney disease. Rise slowly from a sitting or lying position unless you may have a severe drop in blood pressure.


Imdur is contraindicated in the patients with hypersensitivity or rare and unpredictable reactions to other nitrates or nitrites.

Side effects

The most frequent side effect of Imdur is headache, causing dizziness, palpitations, a severe drop in blood pressure when rising from a sitting position, weakness.

Drug interaction

Concomitant use with Sildenafil (Viagra), vardenafil (Levitra), or tadalafil (Cialis) may dangerously decrease the blood pressure and is contradicted. Do not combine Imdur with calcium channel blockers such as diltiazem (Dilacor, Tiazac, Cardizem) and verapamil (Isoptin, Isoptin SR, Calan, Verelan, Verelan PM, Covera-HS)

Missed dose

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double doses of Imdur. Take your usually dose next day in the same regularly time.


Symptoms of overdose include fast or pounding heartbeats, nausea, vomiting, fever, confusion, dizziness a severe throbbing headache, spinning sensation, vision problems, stomach pain, bloody diarrhea, sweating, trouble breathing, cold or clammy skin, fainting, feeling light-headed, seizure.


Store at room temperature between 20-25 C (68-77 F). Store away from moisture, heat, and sunlight. It is not recommended to store in a bathroom and places available for children.


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

How does Lasix work and what pharmaceutical group does it belong to?

Lasix is a diuretic agent. Lasix causes a short term diuresis. Lasix action mechanism is associated with the reabsorbtion block of chloride and sodium ions in the Henle's loop.Lasix works by increasing excretion of K+, Ca2+, Mg2+ out of the organism. Hypotensive effect of the medication is associated with increased elimination of sodium and water.

Which conditions are treated with Lasix?

Lasix is used for the treatment of the following conditions:

  • Edema syndrome in chronic cardiac failure(II - III stage)
  • Cirrhosis
  • Kidney diseases
  • Cerebral edema
  • Hypertensive crisis
  • Hypertension
  • High calcium blood level

What should a patient know before using Lasix?

The Lasix should not be used in cases of:

  • Hypersensitivity
  • Severe renal failure
  • Acute liver failure
  • Ankylurethria
  • Acute glomerulonephritis
  • Hyperglycemic coma
  • Hyperuricemia
  • Arthragra
  • Decompensated mitral or aortal stenosis
  • Hypotension
  • Acute myocardial infarction
  • Pancreatitis
  • Digitalis intoxication

The drug should be used with caution in the following conditions:

  • Prostatic Hyperplasia
  • Systemic lupus erythematosus
  • Diabetes
  • Pregnancy
  • Breastfeeding

Which adverse effects may manifest when using the medication?

The side effects of Lasix include:

  • Cardiovascular system: hypotension, postural hypotension, collapse, tachycardia, arrhythmia, volume of blood circulation decrease.
  • Central nervous system: dizziness, headache, myasthenia, cramp in leg, paresthesia, apathy, adynamia, weakness, drowsiness,
  • Sense organs: vision and hearing disorders.
  • Gastrointestinal tract: appetite reduce, xerostomia, nausea, vomiting, constipations and diarrhea, pancreatitis.
  • Urinary system: oliguria, acute retention of urine, interstitial nephritis, erythrocyturia, decrease of sexual potency.
  • Allergic reactions: purpura, urticaria fever, exfoliative dermatitis, vasculitis, skin rash, shakes, fever.
  • Hematopoietic system: leukopenia, thrombocytopenia, agranulocytosis, anemotrophy.
  • Water-electrolyte balance: hypovolemia, anhydration, hypokalemia, hyponatremia, hypomagnesemia, metabolic alkalosis.

It is not necessary that the side effects will manifest in an individual but the possibility still exist. For more information please consult your health care provider.

Which groups of drugs or specific preparations may interact with Lasix?

The drug is affected by the following:

  • Immunodepresants
  • Aminoglycosides
  • Antimicrobial agents
  • Diuretics
  • Antineoplastics
  • Antimycotics
  • Antiulcer agents
  • Bronchodilating agents
  • Hypotensive preparations
  • Glucocorticosteroids
  • Cardiac glycosides

Tell your doctor about all the herbal preparations as well as prescription drugs that you are currently taking even if they are not on the list.

Important information for the patient:

Lasix is supplied for individual use. Do not use it to treat other conditions not listed in the leaflet. Keep the product out of children reach. Do not reuse any disposable materials if supplied with the preparation.