Generic Dilantin (Phenytoin)
Dilantin is anti-seizure medication used to treat epilepsy.
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Dilantin - opinion

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Common use

Dilantin is anti-seizure medication described as an effective drug which reduces electrical conductance among brain cells by stabilizing the inactive state of voltage gated sodium channels. This medication is used to treat epilepsy (seizures), to prevent post-traumatic epilepsy and epilepsy caused by neurosurgery, ventricular arrhythmias, including intoxication with cardiac glycosides, some forms of Meniere's syndrome, trigeminal neuralgia and many other conditions.

Dosage and directions

Dose of Dilantin in patients treated for non-epileptic disease should be several times lower than in ones with epilepsy. Your dosage should be prescribed by your doctor. A recommended daily dose to treat epileptic seizures is 5 mg per kilo in adults and 4-7 mg per kilo in children. The daily dose should be divided for 1-2 intakes. If to take the medication with food it may reduce its side effects. Correction of the dose is needed in elderly patients, debilitated persons, and patients with certain kidney or liver diseases. Do not use Dilantin suspension at the same time as tube feedings. Do not stop taking this drug without your doctor's permission even if you feel fine as you may have increase in seizures. Do not chew, crush, break, open an extended-release capsule; swallow the whole pill. Shake the suspension before to use it and measure it with a special spoon.


Before to take Dilantin inform your doctor if you have liver or kidney disorder, vitamin D deficiency, diabetes, porphyria, pregnant or plan to become pregnant, breastfeeding. Serious skin reaction to Dilantin may rarely develop in patients of Asian ancestor. This medication can make contraception pharmaceuticals less effective. This drug may change your ability to drive or operate machinery which requires high concentration of attention. Do not take with antacids.


Dilantin is prohibited in patients with liver and kidneys diseases, leukopenia, heart failure, cachexia, porphyria and in patients concomitantly treated with isoniazid, teturamom, aspirin. Cautiousness should be exercised in pregnant or breastfeeding patients (increased risk of malformations and birth defects), ones sick with diabetes.

Possible side effect

Adverse side effects may appear during treatment with Dilantin: dizziness, agitation, tremor, ataxia, nystagmus (involuntary eyes movements), fever, nausea, vomiting, changes in connective tissue (coarsening of facial features, Dupuytren's contracture), allergic reaction (rash, itching). Prolonged use of the medication in patients and especially in children may causes dyspepsia, gingival hyperplasia (overgrowth of the gums), osteopathy, hypocalcemia, megaloblastic anemia. In rare cases lymphadenopathy and hirsutism (excessive and increased hair growth) may appear. Lymph nodes may sometimes painfully swell up. Level of glucose may rise also so it should be used cautiously in patients with diabetes. Weakness of the bones stipulated by interference of Dilantin into the synthesis of vitamin D may appear. Risk of suicidal behavior in patients treated with Dilantin increases. In case of any serious side effects listed above and also ones of allergy seek for immediate medical help.

Drug interaction

Dilantin increases effects of coumarin anticoagulant drugs, while the anticoagulants in their turn increase blood levels of Dilantin which may aggravate risk of toxicity and hemorrhagic complications. Inform your doctor if you are taking digoxin, carbamazepine, clonazepam, corticosteroids (prednisone), cyclosporine, disopyramide, doxycycline, estrogens, felodipine, levodopa, lidocaine, methadone, mexiletine, oral contraceptives, paroxetine, quinidine, tacrolimus, theophylline, phenobarbital, and warfarin as they may decrease blood levels of Dilantin.

Tricyclic antidepressants [Amitriptyline (Elavil, Endep), Desipramine (Norpramin, Pertofrane), Amoxapine (Asendin), Clomipramine (Anafranil), Imipramine (Tofranil), Nortriptyline (Pamelor, Aventyl), Doxepin (Adapin, Sinequan), Protriptyline (Vivactil), Trimipramine (Surmontil)] in large doses diminish a convulsive threshold and in small doses increase it, some of them are able to slow down metabolism of Dilantin and increase its toxicity hereby. Isonicotinic acid, certain antibiotics (levomitsetin), sulfonamides, aminasine are able to increase toxicity of Dilantin.

Dilantin increases hypotention effects of diuretics and other anti-hypertension medications, strengthens action of anapryline and antiarrhythmic medications, thyroid hormone replacement drugs. Dilantin decreases activity of medications for diabetes, affects metabolism of corticosteroids and tetracycline (Vibramycin), influences absorption of diuretics (Furocemide). Dilantin may increase indices of bilirubin, cholesterol, glucose, alkaline phosphatase, liver transaminases in blood tests.

Missed dose

If you missed a dose take it as soon as you remember. If it is almost time of your next dose just skip the missed dose and return to your schedule.


Large doses of Dilantin cause ataxia, nystagmus, diplopia (double vision), extrapyramidal disorder, hyperkinesia (muscular activity), sensory neuropathy. High concentration of Dilantin (more than 50 mg/l) in rare cases may cause aggravation of attacks, sopor (abnormally deep sleep) and coma. Large doses of the medication increase blood levels of glucose in patients who are not sick with diabetes. Blood levels of Dilantin over 20 mg/l in children may lead to acute toxicity: nystagmus, ataxia, mental disorders, joint pain, and in more severe cases bradycardia, ventricular fibrillation, atrial flutter, asystole, and coma. If you suppose that Dilantin was overdosed seek for immediate medical help.


Store tablets, capsules, and suspension of Dilantin at room temperature, 15-30 C (59-86 F).


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

How does Lasix work and what pharmaceutical group does it belong to?

Lasix is a diuretic agent. Lasix causes a short term diuresis. Lasix action mechanism is associated with the reabsorbtion block of chloride and sodium ions in the Henle's loop.Lasix works by increasing excretion of K+, Ca2+, Mg2+ out of the organism. Hypotensive effect of the medication is associated with increased elimination of sodium and water.

Which conditions are treated with Lasix?

Lasix is used for the treatment of the following conditions:

  • Edema syndrome in chronic cardiac failure(II - III stage)
  • Cirrhosis
  • Kidney diseases
  • Cerebral edema
  • Hypertensive crisis
  • Hypertension
  • High calcium blood level

What should a patient know before using Lasix?

The Lasix should not be used in cases of:

  • Hypersensitivity
  • Severe renal failure
  • Acute liver failure
  • Ankylurethria
  • Acute glomerulonephritis
  • Hyperglycemic coma
  • Hyperuricemia
  • Arthragra
  • Decompensated mitral or aortal stenosis
  • Hypotension
  • Acute myocardial infarction
  • Pancreatitis
  • Digitalis intoxication

The drug should be used with caution in the following conditions:

  • Prostatic Hyperplasia
  • Systemic lupus erythematosus
  • Diabetes
  • Pregnancy
  • Breastfeeding

Which adverse effects may manifest when using the medication?

The side effects of Lasix include:

  • Cardiovascular system: hypotension, postural hypotension, collapse, tachycardia, arrhythmia, volume of blood circulation decrease.
  • Central nervous system: dizziness, headache, myasthenia, cramp in leg, paresthesia, apathy, adynamia, weakness, drowsiness,
  • Sense organs: vision and hearing disorders.
  • Gastrointestinal tract: appetite reduce, xerostomia, nausea, vomiting, constipations and diarrhea, pancreatitis.
  • Urinary system: oliguria, acute retention of urine, interstitial nephritis, erythrocyturia, decrease of sexual potency.
  • Allergic reactions: purpura, urticaria fever, exfoliative dermatitis, vasculitis, skin rash, shakes, fever.
  • Hematopoietic system: leukopenia, thrombocytopenia, agranulocytosis, anemotrophy.
  • Water-electrolyte balance: hypovolemia, anhydration, hypokalemia, hyponatremia, hypomagnesemia, metabolic alkalosis.

It is not necessary that the side effects will manifest in an individual but the possibility still exist. For more information please consult your health care provider.

Which groups of drugs or specific preparations may interact with Lasix?

The drug is affected by the following:

  • Immunodepresants
  • Aminoglycosides
  • Antimicrobial agents
  • Diuretics
  • Antineoplastics
  • Antimycotics
  • Antiulcer agents
  • Bronchodilating agents
  • Hypotensive preparations
  • Glucocorticosteroids
  • Cardiac glycosides

Tell your doctor about all the herbal preparations as well as prescription drugs that you are currently taking even if they are not on the list.

Important information for the patient:

Lasix is supplied for individual use. Do not use it to treat other conditions not listed in the leaflet. Keep the product out of children reach. Do not reuse any disposable materials if supplied with the preparation.