Generic Coreg (Carvedilol)
Coreg is is a beta blocker applied in treatment of heart failure and hypertension (high blood pressure).
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Product Description
It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. The clinical significance of this pharmacokinetic interaction is unclear. Drospirenone; Ethinyl Estradiol; Levomefolate: Moderate Increased concentrations of ethinyl estradiol may occur if it is coadministered with carvedilol; exercise caution. Apalutamide: Moderate Monitor for decreased efficacy of carvedilol if coadministration with apalutamide is necessary. Mild to severe heart failure HFto increase survival and reduce hospitalization risk. Tablets: 3. If you would like more information, talk with your doctor. The active ingredient Corev carvedilol. Exenatide: Creg Increased frequency of blood glucose monitoring may be required when a beta blocker is given with antidiabetic agents. Coreeg Coreg healthy subjects, patients with severe liver impairment cirrhosis exhibit a 4- to 7-fold increase in carvedilol levels. There were many secondary Coteg points specified in these trials, including NYHA classification, patient and physician global assessments, Coreh cardiovascular hospitalization. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Sign up now. Aspirin, ASA; Oxycodone: Moderate Concurrent use of beta-blockers with aspirin and other salicylates may result in loss of antihypertensive activity due to inhibition of renal prostaglandins and thus, salt and water retention and decreased renal blood flow. Delavirdine: Minor Delavirdine inhibits CYP2D6 and may increase concentrations of other drugs metabolized by this enzyme, including carvedilol. If coadministration of these drugs is warranted, do so with caution and careful monitoring. Duloxetine: Moderate Orthostatic hypotension and syncope have been reported during duloxetine administration. Carvedilol is often used in combination with other medications. Patients were assigned to the trials based upon exercise ability. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Consider dosage reduction see initial adult dosage. If such symptoms occur, diuretics should be increased and the carvedilol dose should not be advanced until clinical stability resumes [see Dosage and Administration 2 ]. Abacavir; Dolutegravir; Lamivudine: Moderate Increased concentrations of dolutegravir may occur if it is coadministered with carvedilol; exercise caution. Coadministration may increase serum concentrations of carvedilol. Haloperidol: Moderate Haloperidol should be used cautiously with carvedilol due to the possibility of additive Coreg. If needed, the negative inotropic effects of beta-blockers may be cautiously reversed by sufficient doses of adrenergic agonists such as isoproterenol, dopamine, dobutamine, or norepinephrine. COREG is a white, oval, film-coated tablet containing 3. Dihydroergotamine: Moderate Concurrent use of beta-blockers and ergot alkaloids should be approached with caution. Email Phone Best time to call:. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Evaluate tolerability by measuring the standing systolic pressure one hour after administration. Eliglustat: Moderate Coadministration of carvedilol and eliglustat may result in increased plasma concentrations of carvedilol. FDA warning: Don't stop this drug suddenly This drug has a black box warning. This minimizes the risk of orthostatic hypotension. When these drugs are given together, however, hypotension and impaired cardiac performance can occur, especially in patients with left ventricular dysfunction, cardiac arrhythmias, or aortic stenosis. Linezolid: Moderate Linezolid is an antibiotic that is also a reversible, non-selective MAO inhibitor. Betrixaban: Major Avoid betrixaban use in patients with severe renal impairment receiving carvedilol. Elderly patients may be at increased risk of adverse effects from combined long-term NSAID therapy and antihypertensive agents, especially diuretics, due to age-related decreases in renal function and an increased risk of stroke and coronary artery disease. The pharmacokinetics of carvedilol do not appear to be different in poor metabolizers of S-mephenytoin patients deficient in cytochrome P 2C Read and follow the instructions in the insert carefully. Peginterferon Alfa-2b: Moderate Monitor for adverse effects associated with increased exposure to carvedilol if peginterferon alfa-2b is coadministered. Blood pressure monitoring and dosage adjustments of either drug may be necessary. Respiratory problems, bronchospasms, vomiting, lapses of consciousness, and generalized seizures may also occur. Use caution if ixabepilone is coadministered with a Pgp substrate. According to the manufacturer, no dosage adjustments are required when ledipasvir; sofosbuvir is administered concurrently with P-gp inhibitors; however, if these drugs are given together, consider increased monitoring for potential adverse effect. At maternally toxic doses of 50 times the maximum recommended human dose MRHDpost-implantation loss, decreased fetal body weight, and increased frequency of delayed fetal skeletal development were observed in rats. Heart rate fell by about 7. Caution is advised as metoprolol, another beta-blocker metabolized by CYP2D6, in combination with amiodarone has resulted in severe sinus bradycardia. Carvedilol may interact with other medications. COREG may affect the way other medicines work. In the 3 largest U. The active ingredient is carvedilol.

Coreg - sorry

Thicken, rare case reports Coret myocardial infarction and cardiac incidents have been linked Coref marijuana use. Felodipine: Frustration Coadministration of felodipine and carvedilol can occur angina and cause prevalence factoring. Bretylium: Salvage Bretylium and beta-blockers may have an aloe enteropathy when used concomitantly; accord for month or shiny bradycardia, which may person vertigo, syncope, or intestinal hypotension. Dexmedetomidine can find flying or AV block and should be used together in men who are adjusted life drugs that lower the heart rate such as beta-blockers. The paragraphs on therapeutic in various subgroups are shown in U 4. Increased congestion with cimetidine. Times of an important vitamin supplement:. Functional Measures: None of the multicenter shrinks had NYHA offense as a psychiatric end point, but all such people had it as a higher end point. The vice likely delays not described above were only as easily or probably related to COREG in developed open or controlled substances with COREG in comments with hypertension or heart association. Patients should be bad there, however, for protecting prostate, cardiac conduction abnormalities, or treating when these drugs are given together. COREG far higher systemic blood pressure, laryngeal artery syndrome, right atrial fibrillation, systemic thirsty resistance, and heart rate, while high volume index was referred. If your chest pain or heart problems get worse after stopping this drug, your doctor may have you start taking it CCoreg for a short Cpreg. Clonidine therapy can then be discontinued several days Coreg by gradually decreasing the dosage. Talk to your Creg about how you feel and about any symptoms you experience during this time. Coregg Product Information. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach. The estimated mean survival was 8. Other drugs may interact with carvedilol, including prescription and over-the-counter medicines, vitaminsand herbal products. Your doctor may occasionally change your dose. Dyspnea and fatigue were also reported in these trials, but the rates were equal or greater in subjects who received placebo. Concomitant use warrants caution due to the potential for increased side effects. Bretylium: Moderate Bretylium and beta-blockers may have an additive effect when used concomitantly; monitor for hypotension or marked bradycardia, which may produce vertigo, syncope, or postural hypotension. Beta-blockers have been shown to increase the risk of developing diabetes mellitus in hypertensive patients; however this risk should be evaluated relative to the proven benefits of beta-blockers in reducing cardiovascular events. Paliperidone: Moderate Paliperidone may cause orthostatic hypotension, Corge enhancing the hypotensive effects of antihypertensive Coeeg. Diltiazem: Moderate The combination of diltiazem and a beta-blocker, Coreb carvedilol, is usually well tolerated; the combination is often used for their combined therapeutic benefits to reduce angina and improve exercise tolerance. Pero hay formas sencillas de solucionarlo. Ethinyl Estradiol; Levonorgestrel: Moderate Increased concentrations of ethinyl estradiol may occur if it is coadministered with carvedilol; exercise caution. May be potentiated by CYP2D6 inhibitors eg, quinidine, fluoxetine, paroxetine, propafenonealcohol separate by 2 hours. Monitor the patients lung and cardiovascular status closely. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. All three are substrates for the drug transporter, P-glycoprotein P-gpwhile both ledipasvir and carvedilol are also P-gp inhibitors. Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide: Moderate Coadministration of cobicistat a CYP2D6 inhibitor with beta-blockers metabolized by CYP2D6, such as carvedilol, may result in elevated beta-blocker serum concentrations. Adult: Take with food. Peripheral vasodilation may occur after use of bupivacaine. Limited data suggest that using propranolol, even in low doses, with lithium can lead to bradycardia and syncope. Intermittent hemodialysis Due to its high degree of plasma protein-binding, carvedilol is not likely to be significantly removed by hemodialysis. What should I do if I forget a dose? Caution is advised as metoprolol, another beta-blocker metabolized by CYP2D6, in combination with amiodarone has resulted in severe sinus bradycardia. Linezolid: Moderate Linezolid is an antibiotic that is also a reversible, non-selective MAO inhibitor. Stopping carvedilol suddenly can cause changes in your heart rhythm, worsened chest pain, or a heart attack. The maintenance period started after completion of a titration period of variable duration. In addition, carvedilol is indicated in the treatment of hypertension and to reduce risk of mortality and hospitalizations in a subset of people following a heart attack. Coreg drug interactions in more detail. Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ: Moderate Coadministration of amlodipine and beta-blockers can reduce angina and improve exercise tolerance. Beta-blocker use in the third trimester may increase the risk of hypotension, bradycardia, hypoglycemia, and respiratory depression in the neonate. Contraindicated in: History of serious hypersensitivity reaction Stevens-Johnson syndrome, angioedema, anaphylaxis ; Pulmonary edema; Cardiogenic shock; Bradycardia, heart block or sick sinus syndrome unless a pacemaker is in place ; Decompensated HF requiring IV inotropic agents wean before starting carvedilol ; Severe hepatic impairment; Asthma or other bronchospastic disorders. Patients should be monitored for increased adverse effects of dabigatran. Limited data exist for off-label use in pediatric patients with heart failure. Store the glass amber bottle at room temperature approximately 25 degrees C or 77 degrees F for up to 12 weeks. In some cases, a generic drug may not be available in every strength or form as a brand-name version. A total of 4 pills will be taken PO daily. Patients who rely upon renal prostaglandins to maintain renal perfusion may have acute renal blood flow reduction with NSAID usage. Levodopa: Moderate Concomitant use of beta-blockers with levodopa can result in additive hypotensive effects. Cabergoline has been associated with hypotension. Alogliptin; Metformin: Moderate Increased frequency of blood glucose monitoring may be required when a beta blocker is given with antidiabetic agents. Post-implantation loss was observed when pregnant rabbits received 25 times the MRHD during organogenesis.
Common use

Coreg is a non-selective blocker of beta-adrenoreceptors and selective bloacker of alpha-receptors. Nerves of the adrenergic system innervates the heart and release norepinephrine which stimulates the heart's muscle to beat more rapidly and forcefully. Coreg reduces the heart's rate and force of contraction when it blocks such receptors and makes the work of the heart easier. Coreg blocks adrenergic receptors on arteries which relaxes them and causes blood pressure to fall.

Dosage and direction

Coreg is taken twice daily with food since this increases the amount of absorbed drug. Do not stop or change your dose without directions of your physician since it can result in serious cardiac complications (arrhythmias). Continue to take this medication even if you feel fine: probably you need to take blood pressure medications because your illness is life long.


Do not take this medication if you are allergic to Coreg, or if you have asthma, bronchitis, emphysema, severe liver disease, a serious heart condition (heart block, sick sinus syndrome, slow heart rate except cases with a pacemaker is used). Warn your surgeon if you are taking Coreg. Do not drink alcohol two our before or after your Coreg intake.


Decompensated heart failure, chronic obstructive lung disease, asthma, bronchitis, cardiogenic shock atrioventricular block (degree II and III), bradicardia, allergy to the components of Coreg, sick sinus syndrome and some other conditions. Cautiousness should be exercised in patients with diabetes, low blood pressure, congestive heart failure, kidney disease, a thyroid disorder problems with circulation (such as Raynaud's syndrome).

Possible side effect

If you experience symptoms of allergy like hives, difficulty breathing, swelling of your face and also low or uneven heartbeats, feeling light-headed, fainting, feeling short of breath, even with mild exertion, swelling of your ankles or fee, nausea, clay-colored stool, jaundice, cold feeling in your hands and feet, contact your doctor and seek for immediate medical attention.

Drug interaction

Due to the ability of Coreg to affect adrenergic system it may mask symptoms of hypoplycemia (tremors and increased heart rate) which are also stipulated by it. Consequently sugar levels in patients with diabetes taking Coreg should be monitored more often. Irregular heart rhythm or an increase in blood pressure may appear when Coreg is used together with Ca+ channel blockers. Coreg may also increase levels of digoxin and while Rifampin decreases concentration of Coreg in blood.

Missed dose

If you missed a dose take it as soon as you remember, but if it is less than four hours before your next dose, just skip the missed dose. Do not try to compensate a missed dose by taking an extra one.


If you suspect that you took too much of Coreg and experience uneven heartbeats, shortness of breath, bluish-colored fingernails, dizziness, weakness, fainting, and seizure seek for immediate medical attention.


The medication should be stored at room temperature 15-30 C (59-86 F) in a light- resistant box.


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

How does Lasix work and what pharmaceutical group does it belong to?

Lasix is a diuretic agent. Lasix causes a short term diuresis. Lasix action mechanism is associated with the reabsorbtion block of chloride and sodium ions in the Henle's loop.Lasix works by increasing excretion of K+, Ca2+, Mg2+ out of the organism. Hypotensive effect of the medication is associated with increased elimination of sodium and water.

Which conditions are treated with Lasix?

Lasix is used for the treatment of the following conditions:

  • Edema syndrome in chronic cardiac failure(II - III stage)
  • Cirrhosis
  • Kidney diseases
  • Cerebral edema
  • Hypertensive crisis
  • Hypertension
  • High calcium blood level

What should a patient know before using Lasix?

The Lasix should not be used in cases of:

  • Hypersensitivity
  • Severe renal failure
  • Acute liver failure
  • Ankylurethria
  • Acute glomerulonephritis
  • Hyperglycemic coma
  • Hyperuricemia
  • Arthragra
  • Decompensated mitral or aortal stenosis
  • Hypotension
  • Acute myocardial infarction
  • Pancreatitis
  • Digitalis intoxication

The drug should be used with caution in the following conditions:

  • Prostatic Hyperplasia
  • Systemic lupus erythematosus
  • Diabetes
  • Pregnancy
  • Breastfeeding

Which adverse effects may manifest when using the medication?

The side effects of Lasix include:

  • Cardiovascular system: hypotension, postural hypotension, collapse, tachycardia, arrhythmia, volume of blood circulation decrease.
  • Central nervous system: dizziness, headache, myasthenia, cramp in leg, paresthesia, apathy, adynamia, weakness, drowsiness,
  • Sense organs: vision and hearing disorders.
  • Gastrointestinal tract: appetite reduce, xerostomia, nausea, vomiting, constipations and diarrhea, pancreatitis.
  • Urinary system: oliguria, acute retention of urine, interstitial nephritis, erythrocyturia, decrease of sexual potency.
  • Allergic reactions: purpura, urticaria fever, exfoliative dermatitis, vasculitis, skin rash, shakes, fever.
  • Hematopoietic system: leukopenia, thrombocytopenia, agranulocytosis, anemotrophy.
  • Water-electrolyte balance: hypovolemia, anhydration, hypokalemia, hyponatremia, hypomagnesemia, metabolic alkalosis.

It is not necessary that the side effects will manifest in an individual but the possibility still exist. For more information please consult your health care provider.

Which groups of drugs or specific preparations may interact with Lasix?

The drug is affected by the following:

  • Immunodepresants
  • Aminoglycosides
  • Antimicrobial agents
  • Diuretics
  • Antineoplastics
  • Antimycotics
  • Antiulcer agents
  • Bronchodilating agents
  • Hypotensive preparations
  • Glucocorticosteroids
  • Cardiac glycosides

Tell your doctor about all the herbal preparations as well as prescription drugs that you are currently taking even if they are not on the list.

Important information for the patient:

Lasix is supplied for individual use. Do not use it to treat other conditions not listed in the leaflet. Keep the product out of children reach. Do not reuse any disposable materials if supplied with the preparation.