Generic Combipres (Clonidine )
Combipres is an alpha-agonist hypotensive agent to decrease blood pressure employed alone or in combination with other antihypertensive drugs.
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Product Description

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Common use

Clonidine maybe used orally or as patches applied to your skin, it treats high blood pressure. It acts changing concentration of certain chemicals in blood and stimulating alpha2-adrenoceptors in the brain stem that reduces transmission of a signal from brain to other areas in the body. Its action results in a decrease in peripheral resistance, renal vascular resistance, heart rate, and blood pressure.

Dosage and direction

Usually Clonidine is taken twice daily, dosage depends on individual blood pressure response of a patient. Do not use this drug if it was not prescribed to you by your physician. In case you use patches they should be applied to an area of hairless skin on the upper arm or torso, once every 7 days. When you change the patch for a new one, choose a different area of skin.


Avoid drinking alcohol, be especially attentive if you need to drive or make any work which requires high concentration of attention.


Hypersensitivity to Clonidine or any component of the formulation. Contraindication may also include in patients with sick sinus syndrome, bradicardia, atrioventricular block (degree II and III). Cautiousness should be exercised in cases of acute myocardial infraction, Reino syndrome, endogenous depression kidney failure and others.

Possible side effect

Beside of signs of allergic reaction such as hives, difficulty breathing, swelling such side effects may appear: fast or pounding heartbeats, a very slow heart rate, swelling, rapid weight gain, confusion, hallucinations, fever, pale skin, urinating less than usual. If you experience them seek for immediate medical attention.

Drug interaction

Clonidine causes increase of sedative effect of barbiturates, narcotic pain relievers and alcohol. Certain antidepressants may diminish pharmaceutical effect of Clonidine. Kidney damage maybe caused by increased concentration of Cyclosporine when Clonidine is administered concurrently. Concomitant prescription of Clonidine with medications which lower heart rate (beta-blockers) should be done with cautiousness.

Missed dose

If you missed a dose take it as soon as you remember, but if it is almost time of your next dose, just skip the forgotten dose. Do not try to compensate a missed dose by taking an extra one.


If you suspect that you took too much of Clonidine and your blood pressure first becomes too high (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain) and then followed by low blood pressure (fainting, cold feeling, slow heart rate) seek for immediate medical attention.


Tablets and patches should be stored at room temperature 15-30 C (59-86 F) in a light- resistant container away from moisture.


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

How does Lasix work and what pharmaceutical group does it belong to?

Lasix is a diuretic agent. Lasix causes a short term diuresis. Lasix action mechanism is associated with the reabsorbtion block of chloride and sodium ions in the Henle's loop.Lasix works by increasing excretion of K+, Ca2+, Mg2+ out of the organism. Hypotensive effect of the medication is associated with increased elimination of sodium and water.

Which conditions are treated with Lasix?

Lasix is used for the treatment of the following conditions:

  • Edema syndrome in chronic cardiac failure(II - III stage)
  • Cirrhosis
  • Kidney diseases
  • Cerebral edema
  • Hypertensive crisis
  • Hypertension
  • High calcium blood level

What should a patient know before using Lasix?

The Lasix should not be used in cases of:

  • Hypersensitivity
  • Severe renal failure
  • Acute liver failure
  • Ankylurethria
  • Acute glomerulonephritis
  • Hyperglycemic coma
  • Hyperuricemia
  • Arthragra
  • Decompensated mitral or aortal stenosis
  • Hypotension
  • Acute myocardial infarction
  • Pancreatitis
  • Digitalis intoxication

The drug should be used with caution in the following conditions:

  • Prostatic Hyperplasia
  • Systemic lupus erythematosus
  • Diabetes
  • Pregnancy
  • Breastfeeding

Which adverse effects may manifest when using the medication?

The side effects of Lasix include:

  • Cardiovascular system: hypotension, postural hypotension, collapse, tachycardia, arrhythmia, volume of blood circulation decrease.
  • Central nervous system: dizziness, headache, myasthenia, cramp in leg, paresthesia, apathy, adynamia, weakness, drowsiness,
  • Sense organs: vision and hearing disorders.
  • Gastrointestinal tract: appetite reduce, xerostomia, nausea, vomiting, constipations and diarrhea, pancreatitis.
  • Urinary system: oliguria, acute retention of urine, interstitial nephritis, erythrocyturia, decrease of sexual potency.
  • Allergic reactions: purpura, urticaria fever, exfoliative dermatitis, vasculitis, skin rash, shakes, fever.
  • Hematopoietic system: leukopenia, thrombocytopenia, agranulocytosis, anemotrophy.
  • Water-electrolyte balance: hypovolemia, anhydration, hypokalemia, hyponatremia, hypomagnesemia, metabolic alkalosis.

It is not necessary that the side effects will manifest in an individual but the possibility still exist. For more information please consult your health care provider.

Which groups of drugs or specific preparations may interact with Lasix?

The drug is affected by the following:

  • Immunodepresants
  • Aminoglycosides
  • Antimicrobial agents
  • Diuretics
  • Antineoplastics
  • Antimycotics
  • Antiulcer agents
  • Bronchodilating agents
  • Hypotensive preparations
  • Glucocorticosteroids
  • Cardiac glycosides

Tell your doctor about all the herbal preparations as well as prescription drugs that you are currently taking even if they are not on the list.

Important information for the patient:

Lasix is supplied for individual use. Do not use it to treat other conditions not listed in the leaflet. Keep the product out of children reach. Do not reuse any disposable materials if supplied with the preparation.