Generic Alfacip (Alfacalcidol)
Alfacip is used to treat osteoporosis and conditions with impairments of calcium metabolism such as bone loss due to age.
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Product Description

Alfacip - idea

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Common use

Alfacip (an analogue of vitamin D) contains active ingredient Alfacalcidol and administered to treat conditions with impairments of calcium metabolism caused by 1-О± hydroxylation disorders such as when there is reduced renal function. The conditions treated by Alfacip are renal osteodystrophy, hyperparathyroidism (a disorder with parathyroid hormone deficiency, the substance required for the absorption of calcium and phosphorus), hypoparathyroidism, neonatal hypocalcaemia, nutritional and malabsorptive rickets and osteomalacia, pseudo-deficiency (D-dependent) rickets and osteomalacia, hypophosphataemic vitamin D resistant rickets and osteomalacia, osteoporosis.

Dosage and direction

Daily dose of Alfacip is 1 mcg/day. The dose should be reduced in the elderly, neonates and premature infants, children under 20 kg bodyweight.


The patients treated by Alfacip should be regularly tested to avoid hypercalcaemia for plasma levels of calcium, parathyroid hormone, alkaline phosphatase, radiographic and histological investigations. The tests are needed especially for the patients with chronic renal failure because the decline of renal function may be aggravated by prolonged hypercalcaemia.


Patients with hypercalcaemia, metastatic calcification, hyperphosphataemia (except when occurring with hypoparathyroidism) or hypermagnesaemia, vitamin D toxicity or hypersensitivity to the vitamin D or its analogues cannot be treated by Alfacip.

Possible side effect

The following adverse reactions may occur: hypercalcemia, malaise, tiredness, weakness, nausea and vomiting, headache and dizziness, constipation or diarrhea, dry mouth, abdominal or gastrointestinal pain such as heartburn, heart palpitations, bone, muscle and joint pain.

Drug interaction

Long-term treatment with anticonvulsants, including phenytoin, may change vitamin D and calcium metabolism. This results in metabolic bone disease and hypocalcaemia and even seizures. Monitoring of calcium levels in the patients on antiepileptic drugs is required.

Missed dose

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not increase your recommended dose. Take your doses at about the same time each day to avoid missing a dose.


Signs of Alfacip overdose may be the following: high fever, high blood pressure, irregular heartbeat, stomach pain (severe).


Store at room temperature between 59-77 F (15-25 C) away from light and moisture, kids and pets. Do not use after expiration term.


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

How does Lasix work and what pharmaceutical group does it belong to?

Lasix is a diuretic agent. Lasix causes a short term diuresis. Lasix action mechanism is associated with the reabsorbtion block of chloride and sodium ions in the Henle's loop.Lasix works by increasing excretion of K+, Ca2+, Mg2+ out of the organism. Hypotensive effect of the medication is associated with increased elimination of sodium and water.

Which conditions are treated with Lasix?

Lasix is used for the treatment of the following conditions:

  • Edema syndrome in chronic cardiac failure(II - III stage)
  • Cirrhosis
  • Kidney diseases
  • Cerebral edema
  • Hypertensive crisis
  • Hypertension
  • High calcium blood level

What should a patient know before using Lasix?

The Lasix should not be used in cases of:

  • Hypersensitivity
  • Severe renal failure
  • Acute liver failure
  • Ankylurethria
  • Acute glomerulonephritis
  • Hyperglycemic coma
  • Hyperuricemia
  • Arthragra
  • Decompensated mitral or aortal stenosis
  • Hypotension
  • Acute myocardial infarction
  • Pancreatitis
  • Digitalis intoxication

The drug should be used with caution in the following conditions:

  • Prostatic Hyperplasia
  • Systemic lupus erythematosus
  • Diabetes
  • Pregnancy
  • Breastfeeding

Which adverse effects may manifest when using the medication?

The side effects of Lasix include:

  • Cardiovascular system: hypotension, postural hypotension, collapse, tachycardia, arrhythmia, volume of blood circulation decrease.
  • Central nervous system: dizziness, headache, myasthenia, cramp in leg, paresthesia, apathy, adynamia, weakness, drowsiness,
  • Sense organs: vision and hearing disorders.
  • Gastrointestinal tract: appetite reduce, xerostomia, nausea, vomiting, constipations and diarrhea, pancreatitis.
  • Urinary system: oliguria, acute retention of urine, interstitial nephritis, erythrocyturia, decrease of sexual potency.
  • Allergic reactions: purpura, urticaria fever, exfoliative dermatitis, vasculitis, skin rash, shakes, fever.
  • Hematopoietic system: leukopenia, thrombocytopenia, agranulocytosis, anemotrophy.
  • Water-electrolyte balance: hypovolemia, anhydration, hypokalemia, hyponatremia, hypomagnesemia, metabolic alkalosis.

It is not necessary that the side effects will manifest in an individual but the possibility still exist. For more information please consult your health care provider.

Which groups of drugs or specific preparations may interact with Lasix?

The drug is affected by the following:

  • Immunodepresants
  • Aminoglycosides
  • Antimicrobial agents
  • Diuretics
  • Antineoplastics
  • Antimycotics
  • Antiulcer agents
  • Bronchodilating agents
  • Hypotensive preparations
  • Glucocorticosteroids
  • Cardiac glycosides

Tell your doctor about all the herbal preparations as well as prescription drugs that you are currently taking even if they are not on the list.

Important information for the patient:

Lasix is supplied for individual use. Do not use it to treat other conditions not listed in the leaflet. Keep the product out of children reach. Do not reuse any disposable materials if supplied with the preparation.